Skip to content
活动家资讯

活动家资讯

传递会议价值_深度行业分析

  • 商务会议
  • 游学
    • 国内标杆
    • 海外考察
  • 国际展会
  • 会议资讯
  • 演讲嘉宾
  • 发布活动
  • 订单查询

Shan-Ho Chou简历_National Chung Hsing University ProfessorShan-Ho Chou受邀参会演讲_活动家

Posted on 2021年5月14日 By 活动家编辑小助手

Cyclic di-GMP (c-di-GMP) has been found to be widely present in bacterial kingdom, acting as a secondary messenger to control many important cellular activities, such as biofilm formation, biogenesis and action of flagella and pili, and synthesis and secretion of pathogenic factors in diverse bacteria. C-di-GMP is generated by the GGDEF domain-containing diguanlyate cyclases and degraded by the EAL domain- or HD-GYP domain-containing phosphodiesterases. The mechanisms of c-di-GMP biosynthesis and degradation have been characterized in some detail. However, the nature of c-di-GMP receptors and the mechanisms of c-di-GMP-mediated regulation are still not fully understood. In the past several years, a variety of c-di-GMP-binding protein receptors and two RNA-based riboswitches have been described but it is clear that many more remain to be identified. In the past, the PilZ domain is possibly the most important c-di-GMP binding domain, and has been found to be present in association with many different protein domains to carry out a variety of c-di-GMP regulated processes. However, we have found that although PilZ or other reported c-di-GMP binding domains have been intensively studied, there are many bacteria that completely lack any such c-di-GMP binding domains. It indicates that there are other c-di-GMP binders that are not discovered yet. Recently, we have found one novel c-di-GMP binding domain that uses anintriguing binding modecompletely different to anyc-di-GMP binders reported to date. It exhibits a 53-residue motif for recognizing and binding c-di-GMP, using many hydrophobic residues that are highly conserved. It also uses unique peptide backbone amide protons to form two hydrogen-bonds with the c-di-GMP guanine via its Hoogsteen-edge. In addition, it exhibits a stronger binding affinity than PilZ domains, approximately ten fold stronger. Importantly, such a strong binding stems mostly from hydrophobic interactions, not via polar interactions. Thus the discovery of this novel c-di-GMP binding mode will sparkle the next phase of c-di-GMP research.

活动家作为专业第三方嘉宾邀约平台,依托互联网公开数据为您提供嘉宾信息展示服务。若您发现嘉宾信息需要更新或移除,请发送邮件或联系客服。

我们专注于根据您的具体需求(包括演讲议题、会议日期及活动预算等),为您精准匹配各领域专业嘉宾。为高效服务,建议您提前准备好详细活动信息,并拨打客服电话:18911802888(工作日9:00-18:00)。

温馨提示:本服务仅限嘉宾邀约相关事宜,其他需求暂不处理,感谢您的理解与配合。

演讲嘉宾

文章导航

Previous Post: 刘放简历_无锡微纳产业发展有限公司副总经理刘放受邀参会演讲_活动家
Next Post: 张相木简历_中华人民共和国工业和信息化部装备工业司司长张相木受邀参会演讲_活动家

More Related Articles

熊海量简历_北京大学流通业发展中心副主任熊海量受邀参会演讲_活动家 演讲嘉宾
刘亚伟简历_美国卡特中心X项目部主任刘亚伟受邀参会演讲_活动家 演讲嘉宾
测试简历_ 活动家 测试受邀参会演讲_活动家 演讲嘉宾
林 原简历_中科院化学所研究员林 原受邀参会演讲_活动家 演讲嘉宾
孔华威简历_上海中科计算技术研究所所长孔华威受邀参会演讲_活动家 演讲嘉宾
赵华林简历_环保部规财司司长赵华林受邀参会演讲_活动家 演讲嘉宾
  • 跑会指南
  • 会议报道
  • 商业资讯
  • IT互联网
  • 金融财经
  • 医疗医学
  • 能源化工
  • 农林牧渔
  • 综合行业
  • 区块链

手机购票

近期文章

  • 2025CBIIC第十届医药创新与投资大会 在线报名
  • PuppyPang coffee beans - 优质产地咖啡豆直接采购
  • 2025 第二十一届·美沃斯研究型大会 西安 在线报名
  • 2025 美沃斯大会 · 西安 优惠报名
  • 2026年现代林业与智能技术国际研讨会(STMF 2026)
  • 2026年食品科学与先进技术国际研讨会(FSAT 2026)
  • 2026年可持续农业与环境国际研讨会(SAE 2026)
  • 2026年计算金融与金融科技国际研讨会(CFFT 2026)
  • 2026年大数据与计量经济学国际研讨会(BDE 2026)
  • 第五届应用经济学国际研讨会(CAE 2026)

猜你喜欢

运维 移动互联网 云计算 人工智能 消费金融 UWB专利 投融资 FinTech 医药 网络安全 大数据 Chengkok 创业创新 架构 跨境电商物联网 智慧医疗 环保 生物技术智能制造 零售业 新能源汽车 活动家
活动家资讯

蜀ICP备17005018-3号

Copyright © 2025 活动家资讯.

Powered by PressBook Blog WordPress theme